Summit Therapeutics (SMMT) finds itself at a crossroads, with its stock down over 30% in the past year. Conflicting signals from valuation models paint a complex picture: is the biotech firm dramatically overvalued on traditional metrics, or deeply undervalued based on future cash flows?
From a record-breaking public health crisis in South Carolina to a stunning archaeological find in Mexico, here are the major developments you need to know this afternoon, alongside a look at how global politics is reshaping daily life from Havana to your local coffee shop.
A new Congressional Budget Office analysis reveals the substantial financial burden of deploying National Guard and active-duty troops to several U.S. cities last year, with monthly costs for continued operations running into the tens of millions.
The Department of Homeland Security has significantly softened its initial characterization of the events leading to the fatal shooting of Alex Pretti by border agents, now describing the scene as involving 'several civilians' rather than a riot, raising questions about the justification for the use of deadly force.
Three men face felony charges following a viral New Year's shooting from a Dallas overpass, with investigators linking suspects to a separate road-rage attack and uncovering a cache of firearms.
A mail carrier in Lauderhill faces three counts of animal cruelty following the release of surveillance footage allegedly showing him spraying a resident's three small dogs with a chemical irritant during his delivery route.
A group of protesters in Lynwood, California, surrounded and harassed federal air marshals, incorrectly identifying them as immigration enforcement officers. The incident highlights the volatile climate surrounding immigration debates and the risks of misdirected activism.
A rescue operation in Putnam County, Illinois, ended with one fatality and a second worker airlifted to hospital after both became buried in soybeans while working inside a grain storage bin.
Charles Broomfield, who once wore a '#1 Dad' lanyard, now faces murder charges after allegedly confessing to shooting his fiancée and her two teenage sons in their Grand Rapids home, while his own young child was spared.
Harris County deputies executing a parole warrant at a Channelview motel discovered the body of a 33-year-old man with multiple gunshot wounds. Authorities say the detained warrant subject is not currently linked to the killing.
President Donald Trump is expected to nominate Kevin Warsh, a former Federal Reserve governor with a notably more open stance toward Bitcoin, to lead the central bank. The anticipated move has already triggered market reactions and reshaped expectations for U.S. monetary policy.
At its Analyst Day, Korro Bio detailed its lead candidate KRRO-121, an RNA-editing therapeutic designed to tackle hyperammonemia in urea cycle disorders and hepatic encephalopathy by stabilizing a key liver enzyme, positioning it as a potential paradigm shift from current burdensome treatments.
Trane Technologies (NYSE: TT) reported robust Q4 2025 results, driven by exceptional commercial HVAC demand and a record $7.8 billion backlog. While proactive inventory adjustments pressured residential margins, executives project 12-14% adjusted EPS growth for 2026, fueled by strategic acquisitions and sustained commercial strength.
Schneider National's Q4 2025 earnings fell short of expectations, pressured by a sharp late-year drop in freight demand and severe weather. While acknowledging near-term challenges, executives pointed to early signs of market normalization and detailed strategic cost actions aimed at positioning the carrier for an eventual upcycle.
While Morgan Stanley maintains an Overweight rating on PDD Holdings, the firm has removed the e-commerce giant from its Top Picks list, citing heightened regulatory scrutiny and a slower-than-expected consumer recovery in China.
Parker-Hannifin posts record-breaking Q2 fiscal 2026 results, fueled by robust organic growth and margin expansion, particularly in aerospace. The industrial giant raises full-year guidance and details strategic progress on its planned acquisition of Filtration Group Corporation.
Despite a weaker-than-expected volume environment, Norfolk Southern reported in-line cost performance for Q4 and highlighted significant strides in operational safety and efficiency. Executives pointed to a pivotal year of structural change while outlining cost and capital expenditure guidance for 2026.
Clinical-stage biopharma Mineralys Therapeutics has filed its New Drug Application for lorundrostat, a potential treatment for resistant hypertension, following positive results from multiple trials. The move positions the company for a potential 2026 market entry and has drawn upgraded price targets from analysts.
Facing a tough freight environment, Schneider National's leadership outlines a strategy centered on cost discipline, tech investment, and strategic positioning in intermodal and dedicated services to steer toward future profitability.
Kirby Corporation (NYSE: KEX) reported record annual earnings for 2025, fueled by robust free cash flow and strategic capital returns. While Q4 faced seasonal pressures, management highlighted a late-quarter rebound in inland marine and surging demand in power generation, setting the stage for what they project as a year of steady financial performance in 2026.
